Lamine Yamal has been ruled out of Barcelona's Champions League opener against Newcastle United on Thursday after failing to recover from a groin injury in time.
Yamal, 18, went into the international break last week managing some pain and took painkillers to feature in Spain's World Cup qualifiers against Bulgaria and Turkey .
He was subsequently forced to miss Barça's 6-0 LaLiga win against Valencia last weekend and has not trained this week.
As a result, he has not been named in the squad which flies to Newcastle on Wednesday.
Midfielder Gavi and left-back Alejandro Balde are also missing with injuries, but Frenkie de Jong has been cleared to return to action.
Yamal's injury has been a cause for contention between Barça and Spain , with club coach Hansi Flick accus