(CNN) — The NFL season may be young, but the stakes are already high heading into Week 3. Joe Burrow is sidelined again, Patrick Mahomes is in uncharted territory, and a handful of teams are staring down the dreaded 0-3 start.

Here are five things you need to know.

Burrow sidelined again

Bad news in Cincinnati: Joe Burrow is out once again.

The Bengals quarterback – who was placed on injured reserved on Tuesday – suffered turf toe that requires surgery and is expected to miss at least three months, according to reports, derailing another season before it really gets going.

It’s the latest blow in what’s become a frustrating cycle of injuries for Burrow and the Bengals. Still, Cincinnati has opened 2-0 for the first time since 2018, giving the team a little cushion. Backup Jake Br

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