CLEMSON, S.C. (AP) — Steve Angeli threw for 244 yards and two touchdowns before leaving with a lower leg injury, Justus Ross-Simmons hauled in two TD passes and Syracuse upset heavily-favored Clemson 34-21 on Saturday sending the Tigers to their worst start ever under coach Dabo Swinney.

Angeli threw first half TD passes to Ross-Simmons and Darrell Gill Jr. while Will Nixon scored on a 9-yard run as the Orange (3-1, 1-0 ACC) built a 27-14 lead before Angeli left with a non-contact lower leg injury late in the third quarter after rolling out of the pocket.

Rickie Collins added a touchdown pass in relief for Syracuse, which entered the game as a 17 1/2-point road underdog but never trailed.

First-team preseason All-American Cade Klubnik struggled with accuracy and finding open receivers

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