SANTA CLARA, Calif. (AP) — San Francisco quarterback Brock Purdy will miss his second straight game with a toe injury on Sunday against the Arizona Cardinals.

The 49ers downgraded Purdy to out for the game before inactives were due. San Francisco also downgraded starting receiver Jauan Jennings to out because of injuries to his shoulder and ankle.

Mac Jones will start his second game for San Francisco in place of Purdy. Jones threw for 279 yards and three TDs in his first start last week against New Orleans. Adrian Martinez was promoted from the practice squad to be the backup for the game.

The Niners enter the game also missing star tight end George Kittle, who is on injured reserve with a hamstring injury, and No. 1 receiver Brandon Aiyuk, who is on the physically unable to perform li

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