Kyler Murray, already selected for the Pro Bowl twice in his career, helped the Cardinals sweep San Francisco last season, using his “squirrel”-like elusiveness as highlighted by former 49ers defensive tackle DeForest Buckner . To make matters worse for the San Francisco 49ers , their running game hasn’t found its footing in 2025; inside runs are collapsing without success, and their offense isn’t hiding that weakness, which is exactly what the Cardinals’ defensive linemen, like Calais Campbell, are going to take advantage of.

That’s the concerning challenge. Insider Grant Cohn recently laid out openly how the 49ers have historically struggled to contain Murray in the pocket. “On the other side, they struggle against Kyler Murray. They have had trouble keeping him in the pocke

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