Today’s MLB Betting Trends:

The following MLB betting trends are a collection of analytical data, betting systems and strength ratings featured on VSiN and qualified for the MLB games of Monday, September 22, 2025. This report is meant to emulate the process that Steve Makinen and other members of the VSiN Analytics team undergo when handicapping each day’s MLB board.

AJ’s Angles

These are the top MLB betting trends and systems for today’s games, handpicked by VSiN Analyst AJ Makinen.

MLB Series Betting System #7: Small home favorites of -111 to -180 have been terrible in the first game of any homestand, going 356-310 but for -83.58 units and an ROI of -12.5% since the start of the 2022 season

System Matches (FADE ALL): SAN DIEGO (-119 vs MIL), SAN FRANCISCO (-149 vs STL)

Trend: M

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