COLUMBUS, Ohio — Nick Bosa , a standout defensive end for the San Francisco 49ers, will miss the remainder of the 2025 NFL season with a torn ACL, according to a report from ESPN .

The former Ohio State standout suffered the injury during the 49ers’ win Sunday against the Cardinals. It’s the second such injury of his professional career.

Bosa missed most of the 2020 season after tearing the ACL in his left knee. This time, it’s his right knee.

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