VIENNA (AP) — Iran's supreme leader on Tuesday rejected direct negotiations with the United States over his country's nuclear program, likely slamming the door shut on a last-ditch effort to halt the reimposition of United Nations sanctions on Tehran.

Ayatollah Ali Khamenei's remarks, aired on Iranian state television, likely constrain any possible outreach to the U.S. by Iranian President Masoud Pezeshkian, who is in New York for the U.N. General Assembly. Separately, Iranian Foreign Minister Abbas Araghchi held meetings with diplomats from France, Germany and the United Kingdom there over the reimposition of the sanctions, set to take effect Sunday.

Talks with the U.S. represent “a sheer dead end,” Khamenei said.

“The U.S. has announced result of the talks in advance," he added. "The

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