The San Francisco 49ers are off to a 3-0 start to the 2025 NFL season. On Sunday, they enjoyed a successful home opener, defeating the Arizona Cardinals 16-15 on newly signed kicker Eddy Piñeiro's game-winning field goal. That win came at a cost. All-Pro defensive end Nick Bosa suffered a season-ending torn ACL in the first quarter of the game.

Nevertheless, the 49ers are no strangers to overcoming injury adversity. Backups and young players have contributed heavily to help the team remain perfect through three weeks. The following three players have played key roles in the team’s success so far and will continue to do so as the season progresses.

Keys to the San Francisco 49ers’ 3–0 Start in 2025

Christian McCaffrey Fuels San Francisco 49ers’ 3–0 Start

Ever since the 49ers acquired Mc

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