The Oregon Ducks travel to University Park to take on the Penn State Nittany Lions this weekend for the headline event of Week 5 in college football. This is a rematch of last year’s Big Ten Championship, and the Ducks hope to repeat the outcome.

As the game draws closer, hype builds, and oddsmakers are ready to capitalize. There are already numerous betting markets available across top sportsbooks, accessible to those looking to wager on the game.

The oddsmakers favor Penn State as the Nittany Lions are 3.5-point favorites on the best betting apps. The over/under is between 52.5 and 53.5 points.

Oregon vs. Penn State predictions and best bets

Oregon ML : +154 at DraftKings

First Quarter — Oregon +0.5 : -120 at DraftKings

Oregon Over 24.5 Total Points : +100 at Caesars

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