The New England Patriots (2-2) take on the Buffalo Bills (4-0) in a AFC East rivalry matchup in Orchard Park, New York, on Sunday Night Football. Kickoff from Highmark Stadium is set for 8:20 p.m. ET (NBC/Peacock). Let's analyze BetMGM Sportsbook's NFL odds around the Patriots vs. Bills odds and make our expert NFL picks and predictions for the best bets.

New England destroyed the Carolina Panthers 42-13 in Week 4 while covering as a 5.5-point favorite as the Over (41.5) cashed. The Pats gave up the first score in that outing before proceeding to force either a punt, turnover, or missed field goal for all of Carolina's next 9 drives. The Patriots also picked up 2 much-needed special teams TDs in the win, including a first-quarter 87-yard punt return by CB Marcus Jones .

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