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NFL power rankings: Eagles, Bills fall behind 49ers, Lions; Patriots, Colts, Broncos leap for Week 6

The quarter-point of the 2025 NFL season has come and gone with Week 5. There are 13 more weeks left before the playoffs and a lot keeps changing.

Here's keeping up with how all 32 teams stack up against each other going into Week 6, from best to worst, with a new team at the top:

NFL Power Rankings

Nathan Ray Seebeck-Imagn Images

1. San Francisco 49ers 4-1 (previous ranking: 6)

The 49ers got the job done against the rival Rams with gritty defense and Mac Jones once again playing superb in place of Brock Purdy. San Francisco has also enjoyed a healthy Christian McCaffrey again. They have risen back to the top of the loaded NFC.

2. Detroit Lions 4-1 (5)

The

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