Monday Night Football will pit the Jacksonville Jaguars against the Kansas City Chiefs, and kickoff is scheduled for 8:15 p.m. ET at EverBank Stadium in Jacksonville. Kansas City's offense came alive in a win over Baltimore last week, with Patrick Mahomes enjoying his first four-touchdown game since 2023. Meanwhile, the Jaguars are coming off an upset win over the 49ers, and Liam Coen's biggest contribution thus far in his first year as head coach has been igniting the running game. Travis Etienne has produced 426 yards of total offense already and has scored three times, and he has the shortest anytime touchdown scorer odds for Jaguars vs. Chiefs at +145.

Targeting NFL player props is one way to approach NFL odds at online sports betting sites for Monday Night Football in Week 5.

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