By this point of the NFL season, we’ve eliminated some outside noise. Patterns, usage and coaching behavior are clearer now — but midseason surprises still happen. We lean into matchups, volume and inefficiencies with your fantasy plays for Week 6.

Quarterbacks

Start: Dak Prescott, Cowboys at Panthers

Prescott has turned a corner in 2025, showing better pocket presence and command of his short-to-intermediate game. Carolina has struggled to pressure elite quarterbacks and Prescott is playing like one, throwing seven TDs the past two weeks. In this matchup, Prescott should get clean pockets and enough downfield help to deliver strong fantasy value — even without CeeDee Lamb.

Other locks:

—Jalen Hurts vs. Giants

—Jared Goff vs. Chiefs

—Brock Purdy vs. Buccaneers

Avoid: Tua Tagovailoa

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