A week after seizing control of the AFC South with a shootout victory over the Seattle Seahawks 38-35, the Tampa Bay Buccaneers will face another stiff test when they battle the NFC West-leading San Francisco 49ers . San Francisco is coming off a 26-23 victory over the Los Angeles Rams on Thursday Night Football. The Buccaneers are 2-1 in the conference, while the 49ers are 4-0 against NFC foes. The SportsLine model favors the Buccaneers (-3) at home, with both teams bringing 3-2 spread records into the matchup.

There are a number of intriguing matchups on the Week 6 NFL schedule, including Broncos vs. Jets (+7.5) in London, Rams vs. Ravens (+7.5), with Lamar Jackson's availability in doubt, Seahawks vs. Jaguars (-1.5), Lions vs. Chiefs (-2.5) on Sunday Night Footbal

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