Last year saw twice as much Manhattan office space start to be converted into apartments as the year before – a boom that’s poised to change the chemistry of Midtown neighborhoods historically dominated by office towers, hotels and entertainment venues.

Among them: at least four buildings on Third Avenue in the East 40s and 50s and 135 E. 57th St. at Lexington Avenue, once a symbol of the late-1980s office-development craze. The conversions will bring 24/7 energy and domestic warmth to blocks that are typically quiet after dark.

On the other hand, RXR’s conversion of 5 Times Square into 1,250 apartments — which was one of the quartet of West 42nd Street towers that proclaimed a new era for the “Crossroads of the World” — might have a calming effect on the frenetic street scene around i

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