The Arizona Cardinals continue their 2025 NFL regular season schedule with an NFL Week 6 game against the Indianapolis Colts today.

The Cardinals are coming off a 22-21 loss against the Tennessee Titans in their NFL Week 5 game.

The Colts beat the Las Vegas Raiders in the fifth week of the season, 40-6.

This is the first game between Arizona and Indianapolis since 2021, when the Colts defeated the Cardinals in Glendale, Arizona, 22-16.

Follow our live updates of the game, which is being played at the Colts' Lucas Oil Stadium in Indianapolis, for the latest score, news, notes and analysis of the Week 6 NFL game on Sunday, Oct. 12. Expert MLB daily picks: Unique MLB betting insights only at USA TODAY Watch Cardinals at Colts with FUBO (free trial)

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