The Buccaneers defeated the 49ers 30-19 in Week Six. Baker Mayfield completed 17-of-23 attempts for 256 yards and two touchdowns, with no interceptions for a 139.0 passer rating. The Bucs' defense recorded four sacks and two interceptions on the day at Raymond James Stadium.

The Buccaneers first offensive drive ended in a punt after a false start penalty backed the Bucs up to third-and-17. Tampa Bay then capitalized off a Kindle Vildor interception. Vildor picked off Mac Jones and returned it to the San Francisco 12-yard line for 13 yards. In two plays, the Bucs were in the end zone off a two-yard Rachaad White rush up the middle, providing the home team with a 7-0 lead.

The 49ers ensuing drive ended on a third-down sack by Elijah Roberts on Mac Jones for a loss of 10 which forced an Edd

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