Scientists reverse Alzheimer’s in mice using nanoparticles

Researchers have reversed Alzheimer’s symptoms in mice using bioactive nanoparticles that restore blood-brain barrier function. The therapy rapidly cleared toxic amyloid-beta and improved behavior, highlighting vascular health as a promising new target for human Alzheimer’s treatments.

Hyderabad: In a stunning scientific breakthrough, an international research team has demonstrated a novel nanotechnology strategy that effectively reverses Alzheimer’s disease pathology in mice.

Instead of targeting neurons directly, the therapy focuses on repairing the brain’s critical defense system i.e. blood-brain barrier (BBB).

The BBB is the vascular gatekeeper responsible for clearing toxic waste, like the protein amyloid-beta (Aβ), from the brain. In individuals with Alzheimer’s, this clearance s