Synopsis: New research reveals gestational diabetes signs emerge in the first trimester, with over 140 biomarkers—like low PAPP-A and high glucose/cholesterol—identified in a review of 130 studies. This supports early screening for prevention, improving maternal and fetal outcomes. Experts advocate multidisciplinary care and personalized interventions but caution on validation needs and implementation challenges in resource-limited settings.

For years, gestational diabetes has been treated as a condition that emerges midway through pregnancy. But new evidence suggests that the biological signs of the disorder start showing up much earlier, even before many women realise they are at risk.

A new scoping review of more than 130 studies has found that subtle metabolic and inflammatory chang

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