Oct 4, 2025; Tallahassee, Florida, USA; Miami Hurricanes wide receiver Malachi Toney (10) celebrates with teammates after scoring a touchdown during the second half against the Florida State Seminoles at Doak S. Campbell Stadium. Mandatory Credit: Robert Myers-Imagn Images

Friday night marks the start of the Week 8 ACC college football slate, with the action turning up the volume as a national championship contender takes on a feisty team that would love nothing more than to pull off the upset.

The Miami Hurricanes (5-0, 1-0 ACC) are looking like one of the most dominant teams in the country on a march towards the College Football Playoff. This week, standing in their way is a game against the Louisville Cardinals (4-1, 1-1 ACC), who will be upset-minded road underdogs when this game kicks off from Hard Rock Stadium in Miami Gardens, Florida.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Stream Miami vs. Louisville

Miami vs. Louisville game odds

All college football odds via BetMGM

  • Spread: Miami -13.5 (-115), Louisville +13.5 (-105)
  • Money Line: Miami -600, Louisville +425
  • Over-Under: Over 51.5 (-115), Under 51.5 (-105)

Miami vs. Louisville prediction, pick:

Miami is the real deal. In past seasons, they have had the misstep and fallen flat on their faces. Such is not the case with this year's team. The Hurricanes are loaded with offensive and defensive talent.

Carson Beck looks rejuvenated at Miami, completing 73.4% of his passes with 11 touchdowns already as he continues to unlock star freshman Malachi Toney (29 receptions, 375 yards, 3 TD) in the passing game.

Louisville, which just suffered its first loss of the year to a tricky Virginia team that people need to be on the lookout for, has the QB talent in Miller Moss to push Miami if he can get hot. That may be the issue, though. Miami is surrendering just 205 passing yards per game, which is inflated by some garbage-time stats teams have put up.

Miami is ready to go and churns out another strong victory in ACC play to continue its march to the conference title game and College Football Playoff bid.

Prediction: Miami 31, Louisville 14

Best Bet: Miami -13.5

Miami vs. Louisville channel, start time, streaming:

Time: 7 p.m. ET

TV Channel: ESPN

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Miami vs. Louisville: Week 8 College Football Betting Odds, Prediction

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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