Rams wide receiver Puka Nacua was ruled out on Friday for a matchup with the Jacksonville Jaguars on Sunday in London.
Head coach Sean McVay delivered the expected verdict on the status of Nacua on Friday.
Nacua sustained a sprained left ankle in the second quarter of Sunday's 17-3 victory over the Baltimore Ravens. He briefly returned in the second half, albeit in a limited capacity.
The Rams (4-2) have a bye in Week 8, which would afford Nacua multiple weeks to recover.
Jordan Whittington, who has 10 receptions for 112 yards this season, likely would see a bigger role this week in the absence of Nacua. Davante Adams is the second-leading receiver on the roster with 26 receptions for 396 yards and three touchdowns.
Nacua, 24, has 54 catches for 616 yards and two TDs and leads the tea