Atlanta Falcons at San Francisco 49ers odds, picks and predictions

Atlanta Falcons quarterback Michael Penix Jr. (9) throws downfield against the Buffalo Bills at Mercedes-Benz Stadium Atlanta, Georgia.

The Atlanta Falcons (3-2) battle the San Francisco 49ers (4-2) on Sunday Night Football at Levi's Stadium. Kickoff in Santa Clara, California, is scheduled for 8:20 p.m. ET (NBC). Let's analyze BetMGM Sportsbook's NFL odds around the Falcons vs. 49ers odds and make our expert NFL picks and predictions for the best bets.

Atlanta has won back-to-back games after taking down the Buffalo Bills 24-14 on Monday Night Football and covering as a 4-point home underdog with the Under (50) hitting. QB Michael Penix Jr. threw for 250 yards and a TD with WR Drake London (10 receptions, 158 yards, TD) being the top target. RB Bijan Robinson was the offensive workhorse with 19 carries for 170 yards, tying a career-high, and a TD -- an 81-yard house call in the second quarter, the longest run in the NFL this season.

San Francisco has lost 2 of its last 3 games after falling 30-19 against the Tampa Bay Buccaneers last Sunday as a 3-point road underdog with the Over (47.5) hitting. QB Mac Jones threw for 347 yards, but had 2 INTs. WR Kendrick Bourne hit a career-high with 142 yards on 5 receptions.. The 49ers could not overcome their numerous injuries; WR Jauan Jennings played with an ankle sprain and 5 broken ribs in the losing effort. He's out this week.

The Falcons won the last meeting 28-14 in 2022, but the 49ers lead the all-time series 48-33-1.

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Falcons at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:01 a.m. ET.

Moneyline (ML): Falcons +105 (bet $100 to win $105) | 49ers -125 (bet $125 to win $100)
Against the spread (ATS): Falcons +1.5 (-110) | 49ers -1.5 (-110)
Over/Under (O/U): 47.5 (O: -110 | U: -110)

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SUNDAY NIGHT FOOTBALL: Best prop bets

Falcons at 49ers key injuries

Falcons

S Billy Bowman Jr. (hamstring) out
TE Feleipe Franks (calf) questionable
T Jake Matthews (ankle) questionable
WR Ray-Ray McCloud (not injury related) out
WR Darnell Mooney (hamstring) questionable
CB Clark Phillips III (triceps, illness) out
LB Jalon Walker (groin) out

49ers

CB Renardo Green (neck) questionable
DE Yetur Gross-Matos (knee, hamstring) out
WR Ricky Pearsall (knee) out
QB Brock Purdy (toe) out
CB Upton Stout (shoulder) questionable
LB Fred Warner (ankle) out

Falcons at 49ers picks and predictions

Prediction

Falcons 27, 49ers 23

Moneyline

BET FALCONS (+105).

Since losing 30-0 against the Carolina Panthers in Week 3, the Falcons have turned a new leaf, evidenced by their 10-point win over the Bills last week and a 2-game winning streak. Penix has done a great job commanding the offense while limiting turnovers, and they have found their rhythm in the run game.

Unfortunately for the 49ers, they have been on the wrong end of too many injuries this season, which has caught up to them, losing 2 of their last 3. Even at home, Sunday night will be an uphill battle.

Against the spread

PASS.

There is better value on the Falcons' moneyline.

Over/Under

BET OVER 47 (-110).

The 49ers' defense has taken a beating this season, especially over their last 3 games, allowing at least 23 points in each game. Offensively, Jones has willed the team into the end zone, eclipsing at least 16 points in each game this season. They have hit the over in each of their last 3 games and in 4 of their last 5.

The Falcons have scored 58 points total over their previous 2 games and have scored at least 20 points in 4 of their 5 games. They have allowed 27 or more points in 2 of their last 3 games and at least 23 points in 3 of their 5 games.

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This article originally appeared on Sportsbook Wire: Atlanta Falcons at San Francisco 49ers odds, picks and predictions

Reporting by Seth Orlemann, Sportsbook Wire / Sportsbook Wire

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