A 1920s Spanish Colonial Revival in Beverly Hills once home to Madonna, meticulously restored by Diane Keaton and later the residence of “Glee” creator Ryan Murphy has listed for $25 million, The Post has learned.

Located at 820 North Roxbury Drive, the approximately 8,434-square-foot home was originally designed in 1927 by Ralph C. Flewelling, the architect behind Beverly Hills’ City Hall.

But it was Diane Keaton, who died this month at the age of 79 from pneumonia, who especially stands out in the home’s history. Beyond a respected actress, she was also known as a prolific home renovator and flipper — a successful side career many didn’t know she had. 20

When Keaton bought the home in 2007 for $8.1 million, she enlisted longtime collaborator Stephen Shadley to help restore an

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