The second day of 2025-26 college basketball season openers continue on Tuesday, Nov. 4, and defending ACC champion and the sixth-ranked Duke Blue Devils take on the Texas Longhorns in a 2025 Dick Vitale Invitational matchup at 8:45 p.m. ET at Spectrum Center in Charlotte, N.C. That's the headliner of the day, and the Blue Devils are the 8.5-point favorites in the latest college basketball odds for Tuesday, with the over/under at 152.5.

Other college basketball lines of note include No. 1 Purdue (-33.5) vs. Evansville, No. 9 Kentucky (-30.5) vs. Nicholls State, No. 10 Texas Tech (-34.5) vs. Lindenwood. With a lot of early-season mismatches on the board, what are the college basketball best bets for Tuesday? Before locking in any college basketball picks, you'll want to see the college ba

See Full Page