A UPS cargo plane crashed and exploded in a massive fireball Tuesday while taking off from the company's global aviation hub in Louisville, Ky., killing at least three people and injuring 11 — numbers that were likely to grow, the state's governor said.

The plane crashed about 5:15 p.m. local time as it was departing for Honolulu from Louisville's Muhammad Ali International Airport, the Federal Aviation Administration said.

"Right now we believe we have at least three fatalities, though I believe that number is going to get larger. We have at least 11 injuries, some of them very significant," Gov. Andy Beshear said.

Video showed flames on the plane's left wing and a trail of smoke. The plane then lifted slightly off the ground before crashing and exploding in a huge fireball.

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