A UPS cargo plane has crashed and exploded in a massive fireball while taking off from the company's global aviation hub in Louisville, Kentucky, killing at least four people and injuring 11.

The plane, carrying three people, was departing for Honolulu from UPS Worldport at Louisville Muhammad Ali International Airport when it crashed.

Video showed flames on the plane's left wing and a trail of smoke. The plane then lifted slightly off the ground before crashing and exploding in a huge fireball.

Video also revealed portions of a building's shredded roof next to the end of the runway.

At least four people were killed, said airport spokesman Jonathan Biven.

Among the 11 who were hurt, some had "very significant" injuries, Kentucky Governor Andy Beshear said.

"Anybody who has seen the i

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