First responders were searching for more victims Wednesday after a UPS cargo plane crashed and exploded in a massive fireball at the company’s global aviation hub in Kentucky, killing at least nine people, authorities said.

Gov. Andy Beshear again predicted the death toll in Louisville would grow and said 16 families gathered at a reunification center “have reported loved ones unaccounted for.”

The plane crashed about 5:15 p.m. Tuesday as it was departing for Honolulu from UPS Worldport at Louisville Muhammad Ali International Airport. Video showed flames on the plane’s left wing and a trail of smoke. The National Transportation Safety Board was sending a team of investigators.

There were “extra smaller explosions” at Kentucky Petroleum Recycling, but it could have been worse, the governor said. Grade A Auto Parts was also hit.

University of Louisville Hospital said two people were in critical condition in the burn unit Wednesday and that 13 others had been treated and discharged. Norton Hospital said it had released three people.

The airport is 7 miles (11.2 kilometers) from downtown Louisville, close to the Indiana state line, residential areas, a water park and museums. A shelter-in-place order was in effect for a quarter of a mile (400-meter) radius, as officials monitored air quality. People in the immediate area were told not to drink tap water.

Beshear said he didn’t know the status of the three crew members aboard the plane, a McDonnell Douglas MD-11 made in 1991. It wasn’t clear if they were being counted among the dead.