The Ohio State Buckeyes arrive at Ross-Ade Stadium as the No. 1 team in the country. As long as the Buckeyes are No. 1, you can expect each opponent to give its best effort to pull off the upset. That sentiment remains true this weekend with the 2-7 Purdue Boilermakers, desperately seeking a signature win for 2025.

As the game draws closer, hype builds, and sportsbooks are ready to capitalize. There are already numerous betting markets available across the top betting apps for those looking to wager on the game.

The oddsmakers favor Ohio State as the Buckeyes are 29.5-point favorites across the best Ohio sportsbooks . The over/under is between 47.5 and 48.5 points.

Ohio State vs. Purdue predictions and best bets

Purdue’s team total is being offered at 8.5, but alternative totals ar

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