Buffalo Bills quarterback Josh Allen (17) rushes against the Houston Texans in the second half at NRG Stadium in Houston, Texas.

The Buffalo Bills (7-3) visit the Houston Texans (5-5) in a Week 12 matchup on Thursday Night Football. Kickoff from NRG Stadium in Houston, Texas, is for 8:15 p.m. ET (Prime Video). Let's analyze BetMGM Sportsbook's NFL odds around the Bills vs. Texans odds and make our expert NFL picks and predictions for the best bets.

The Bills throttled the Tampa Bay Buccaneers 44-32 Sunday as 6-point favorites while the Over (46.5) cleared. QB Josh Allen was a monster becoming the first quarterback with 2 games of 3 passing TDs and 3 rushing TDs. He also passed Peyton Manning as the leader in passing touchdowns (290) by the age of 30. Overall, Allen was 19-for-30 for 317 yards, 3 TDs and 2 INTs while rushing 6 times for 40 yards and 3 TDs.

The Texans have won 2 straight after surviving a scare by the Tennessee Titans, as 5.5-point road favorites, in a 16-13 win Sunday. QB Davis Mills, filling in for starter C.J. Stroud (concussion), went 26-for-41 for 274 yards, 1 TD and no INTs. WR Nico Collins had 10 targets he converted to 9 catches for 92 yards and a score.

These teams met Oct. 6, 2024, in Houston with the Texans coming away with a 23-20 win as 1-point favorites.

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Bills at Texans odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:29 p.m. ET.

  • Moneyline (ML): Bills -275 (bet $275 to win $100) | Texans +225 (bet $100 to win $225)
  • Against the spread (ATS): Bills -5.5 (-110) | Texans +5.5 (-110)
  • Over/Under (O/U): 43.5 (O: -105 | U: -115)

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THURSDAY NIGHT FOOTBALL: Best prop bets

Bills at Texans key injuries

Bills

  • WR Mecole Hardman (calf) out
  • TE Dalton Kincaid (hamstring) out
  • WR Curtis Samuel (elbow, neck) out

Texans

  • S Jalen Pitre (concussion) out
  • QB C.J. Stroud (concussion) out

Bills at Texans picks and predictions

Prediction

Bills 21, Texans 20

Moneyline

Thursday games are wonky, but the Bills should still have enough moxie to get it done. There's no bet here, though, at -275.

Instead, go with JAMES COOK ANYTIME TOUCHDOWN (-105). He hasn't scored in 3 straight games after touching paydirt 7 times in the first 7 games. After Allen took 3 in last week, they will look to Cook to punch it in.

BetMGM has a No Sweat Token with minimum odds of -300 to use if you want some insurance.

Against the spread

LEAN TEXANS +5.5 (+100) here. Their defense is awesome. They're first in total yards (277.1) and points (16.3) allowed per game. Buffalo is a little sketchy on the defensive side of the ball, and Houston has a couple of backs they'll use to sustain drives.

Over/Under

If you paid attention to the previous section, you can probably figure out we're going UNDER 43.5 (-115). Buffalo is 5-5 O/U in its last 10, but 4 of those came in the last 6 games. Houston is 3-6-1 O/U in its last 10.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Buffalo Bills at Houston Texans odds, picks and predictions

Reporting by Ryan Dodson, Sportsbook Wire / Sportsbook Wire

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