New research has revealed that a 10% lactate clearance threshold is a stronger predictor of in-hospital mortality for emergency department patients with sepsis or septic shock than PCT clearance. Although an optimal procalcitonin clearance (PCTc) cutoff of 23.1% was identified, it lacked statistical significance for survival. The study was published in the Frontiers in Medicine journal by Razan D. and colleagues.

This retrospective cohort series included 574 adult patients with sepsis or septic shock presenting to a tertiary care emergency department (ED) in Lebanon between November 2018 and March 2024. Data collection included patient demographics, comorbidities, therapeutic interventions, and serial biomarker readings, including procalcitonin and lactate. The clearance rates were calc

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