Today, the Cleveland Browns take on the San Francisco 49ers in Week 13 of the 2025 NFL season. The Browns (3-8) are coming off of a win over the Raiders that saw Shedeur Sanders pick up a victory in his first career start. We’ve used that line to death, but now it’s still up to the rookie quarterback to show that he can deliver more than just a win over a bad team. The 49ers (8-4) have had a solid season, although they have some uncertainty at the quarterback position after how Mac Jones played, whereas Brock Purdy threw three interceptions last week.
The 49ers play smart football generally, but they don’t pressure the quarterback very well, which plays into the Browns’ favor. With the high winds expected, San Francisco might have trouble moving the ball themselves; can Cleveland’s defens

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