It's No. 1 vs. No. 2 in the Big Ten Championship game. It's familiar territory for top-ranked Ohio State. But this is new ground for the "home" team as No. 2 Indiana looks to make history Saturday night at Lucas Oil Stadium in Indianapolis.

The winner is the College Football Playoff’s top seed and the loser should still finish in the top four, especially if the game is competitive. (And especially if the loser is Ohio State.) Think of this matchup as a barometer for both teams heading into the postseason.

Saturday's title game could also help decide the Heisman Trophy as Buckeyes QB Julian Sayin and Hoosiers QB Fernando Mendoza are both among the favorites heading into the final weekend before Heisman votes cast their ballots.

Here's what you need to know about the game and who we think will win:

Big Ten Championship game: Ohio State vs Indiana

  • Records: Ohio State (12-0), Indiana (12-0)
  • Time/TV: Saturday, 8 p.m., FOX
  • Where: Lucas Oil Stadium, Indianapolis

Big Ten Championship game predictions

  • Ohio State 27, Indiana 17: Curt Cignetti's offense feasts on most Big Ten defenses. This is not your ordinary Big Ten defense, though. The Buckeyes keep winning with an anaconda defense that suffocates opponents. Pair that with steady-handed quarterback Julian Sayin and the best receiving corps in the country, and you get the nation's most complete team. I've been on the Buckeyes to win the national championship since August. I'm not fading them now. — Blake Toppmeyer
  • Indiana 27, Ohio State 24: I just can't get over what the Ohio State defense has faced, instead of what it has done. Who have the Buckeyes played this season that could actually stress their defense? Texas? In Arch Manning's first start? Washington? Illinois? Come on. The Hoosiers will be a completely different animal, a multiple offense with an accurate quarterback who can make every throw — and scramble and get critical yards. One more thing: Hoosiers have 34 sacks and have forced 24 turnovers. The defense will get enough stops, and Indiana will be the No.1 seed in the CFP. — Matt Hayes
  • Ohio State 34, Indiana 16: Ohio State's historically good defense is going to be tested by Indiana and possible Heisman Trophy winner Fernando Mendoza. This is a group with no weak links, nearly unmatched depth and all-everything talent such as safety Caleb Downs, who might be the best pound-for-pound player in college football. The Buckeyes are on a collision course for a repeat national title and won't be tripped up even by the mighty Hoosiers. — Paul Myerberg

Big Ten Championship game betting odds

Odds via BetMGM, as of Dec. 5.

  • Spread: Ohio State (-4)
  • Over/under: 47.5
  • Moneyline: Ohio State (-200)

This article originally appeared on USA TODAY: Big Ten Championship game Ohio State vs Indiana prediction, keys to game

Reporting by Paul Myerberg, Blake Toppmeyer and Matt Hayes, USA TODAY / USA TODAY

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