“American Pickers” has a large and loyal fan following, and if you don’t believe it just check the numbers.

And one number — 27 — stick out there.

That is how many seasons the beloved show has had, but it looks like that might also be where it all comes to an end. One of the show’s stars, Danielle Colby, spilled the beans in an Instagram video celebrating her 50 th birthday Thursday.

“Something is happening that I have to talk to you about,” she said.

She then ran down how her birthday was going — including waking up and smoking a joint and then going to a pancake house — before getting into other life developments.

“Simultaneously, multiple things are happening,” she said. “I’m 50 years old today. We have just opened the Ecdysiast Arts Museum that I have wanted to open my entir

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