Amy Schumer has kept things transparent about her weight loss journey. The choice was an honest one, one that the comedian-turned-actor came to after entering the film scene. As she explained to The Hollywood Reporter in March 2022, "Everybody on camera is doing this s***, I just wanted to be real about it." On the " Howard Stern Show " in January 2025, the comedian revealed that three years prior, she had used the weight loss drug Wegovy, which had a successful result. Dropping down 30 pounds, the celebrity saw a major transformation in her body, but also admitted to feeling as though the side effects of the medication were making her shrivel away.

Wegovy had Schumer experiencing extreme nausea, which she described as a horrible experience. She eventually made the decision to quit

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