Nearly two decades ago—when a jam-packed screening room beneath the Portland Art Museum rang with applause—the hometown premiere seemed to all involved the dawn of a soon-to-be-formidable filmography for brothers Arnold and Jacob Pander. Then, life happened.

Scions of Dutch artist Henk Pander and indie comic legends in their own right, the brothers Pander had been developing their filmmaking chops ever since early work on Drugstore Cowboy storyboarding and building props for de facto mentor Gus Van Sant led to a string of high-profile commercials, shorts and music videos for acts like the Dandy Warhols and DJ Howie B. Then-titled Selfless , their long-awaited feature debut brought together Hollywood heavies like Mo Gallini ( 2 Fast 2 Furious , Mulholland Drive ) and local up-and-c

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