Ten years ago, a handful of genomic pioneers realized something was missing. The main meeting of Advances in Genome Biology and Technology (AGBT) celebrated technical progress and showcased the most dazzling sequencing innovations. But when it came to the messy, real-world complexities of using those tools in medicine, there was no forum. The clinicians, the payers, the regulators, the health systems—the people who had to actually make precision medicine work—weren’t in the room.

So Michael Talkowski, PhD, a leading figure at Massachusetts General Hospital and the Broad Institute, along with Eric Green, MD, PhD, who at the time was just a few years into his tenure as director of the National Human Genome Research Institute (NHGRI), and a few other colleagues, launched a bold experiment: a

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