After a thrilling opening weekend, the Week 2 college football schedule features just one Top 25 showdown. The No. 18 Oklahoma Sooners host the No. 15 Michigan Wolverines at OU Memorial Stadium on Saturday at 7:30 p.m. ET. The Sooners opened the season with a 35-3 victory over Illinois State, while Michigan cruised to a 34-17 win over New Mexico. According to the latest Week 2 college football odds, the Sooners are favored by 5.5 points, while the over/under for total points scored is 46. SportsLine's model is backing Michigan, which is 12-3 in its last 15 games on the road, to cover the spread in over 60% of simulations on Saturday.

The model is also backing Duke (+3) to cover at home against Illinois, while the Over (47.5) hits more than 60% of the time in Vanderbilt vs. Virginia Tech.

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