No team performed worse against the spread (ATS) than the Titans in 2024 as they went just 2-15. Meanwhile, no team had more ATS victories than the Broncos' 12, and it just so happens that you can make Week 1 NFL picks on Titans vs. Broncos. Denver is a .5-point favorite, per the latest Week 1 NFL odds , making Bo Nix and the Broncos one of the biggest favorites of the opening slate. Should you expect these NFL betting trends to carry over into a new season?

Other games with NFL lines of 5 or more points include Bengals vs. Browns (+5.5), Saints vs. Cardinals (-6.5) and Giants vs. Commanders (-6). Meanwhile, the slimmest of the Week 1 spreads is Dolphins vs. Colts (-1). If you are looking for NFL picks, NFL parlays, Fantasy football rankings or NFL DFS picks for Week 1, SportsLine has y

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