The Week 1 NFL schedule has arrived, and several teams will be looking to make a statement with an early-season victory. The Green Bay Packers made the playoffs in 2024 but were ousted by the Philadelphia Eagles in the Wild Card Round. Green Bay opens the 2025 NFL season with an NFC North showdown against the Detroit Lions on Sunday at 4:25 p.m. ET. Detroit is 8-0 in its last eight games on the road, but the Lions are 2.5-point underdogs, according to the latest Week 1 NFL odds. SportsLine's model is backing Green Bay, which is 10-4 in its last 14 games at home, to handle business at Lambeau Field and cover the spread in well over 50% of simulations.

The model is also backing the Jaguars (-3.5) to cover at home against the Panthers, while the Over (45.5) hits in nearly 70% of simulations

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