The San Francisco 49ers will face the Seattle Seahawks in Week 1 of the NFL season on Sunday, September 7, 2025. The game is scheduled to kick off at 4:05 PM ET at Lumen Field in Seattle. Fans can watch the game live on FOX.

The 49ers are hoping for a strong start after a disappointing 6-11 record last season. A key concern for the team is the health of running back Christian McCaffrey, who appeared on the injury report this week. McCaffrey has been a dynamic player when healthy, but injuries have affected his performance throughout his career. The 49ers will need him to be at his best if they want to compete this season.

On the other side, the Seahawks are introducing quarterback Sam Darnold, who is making his regular-season debut for the team. Darnold, who previously had a successful season with the Minnesota Vikings, signed a three-year contract with Seattle worth $100.5 million. At 28 years old, he aims to establish himself as the franchise quarterback for the Seahawks, who narrowly missed the playoffs last year with a 10-7 record.

This matchup is highly anticipated, as both teams are looking to improve their standings in the NFC West. Fans are encouraged to tune in to catch all the action, but regional restrictions may apply.

For those unable to watch the game on local channels, there are several streaming options available. Services like Fubo, YouTube TV, and DirecTV Stream offer FOX in their packages, allowing fans to stream the game online. Additionally, using a virtual private network (VPN) can help viewers bypass any blackout restrictions and access the game from anywhere in the U.S.

As the season kicks off, both teams will be eager to start strong and set the tone for the weeks to come.