The San Francisco 49ers will take on the Seattle Seahawks in Week 1 of the NFL season on Sunday at Lumen Field.

How to Watch 49ers vs Seahawks

Date: Sunday, September 7, 2025

Time: 4:05 PM ET

Channel: FOX

Stream: Fubo ( try for free )

Christian McCaffrey popped up on the 49ers' injury report on Thursday, and San Francisco will be holding their breath all season long in the hopes that their superstar running back can stay relatively healthy this year. When he is right, McCaffrey is one of the most dynamic players in the league, but injuries have plagued him throughout his entire career.

The 49ers had a disappointing 6-11 record last year and will look to get back into contention, but if they have to do so without McCaffrey, it will be an uphill battle.

Sam Darnold is set to ma

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