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While safe when used in a clinical setting, ketamine is also used illicitly and sometimes mixed with other drugs.

Recent celebrity news has increased public awareness and interest in the drug.

Ketamine overdoses depress the central nervous system and cannot be reversed by naloxone.

Medical examiners have seen an increase in ketamine-involved deaths in South Florida this year.

In the first half of 2025, ketamine was present in 33 deaths in Miami-Dade County, according to toxicology reports.

"We first started noticing that there's a lot of ketamine in our cases that also involve other drugs," said Diane Moore, director of toxicology at the Miami-Dade Medical Examiner Department.

"I'm like 'there's ketamine again, there's ketamine again,' and I'm reading the history

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