For years, injuries have been one of the 49ers ' biggest road blocks as the franchise continues in their pursuit of their first Super Bowl title since 1994. That continues to be the case in 2025, as the 49ers are currently dealing with several notable injuries, including George Kittle's recently-sustained hamstring injury that will likely sideline him for 3-5 weeks, according to NFL Media .

Kittle sustained the injury during the first half of San Francisco's Week 1 win over Seattle. He exited the game at that point and was slated to undergo and MRI on Monday. Prior to getting hurt, Kittle had already caught four passes for 25 yards that included a 5-yard touchdown that gave the visitors a 7-0 lead. Colton McKivitz contract: 49ers give stalwart OL team-friendly extension as p

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