Matt's quarterback (QB) fantasy football start 'em, sit 'em picks for Week 2 of 2025. His QB lineups advice for Week 2 fantasy football start/sit decisions.

With the Vikings and Bears concluding Week 1 of the fantasy football season, it is time to crunch the film and data and paint a picture of what to expect as we look at the slate of games set for Week 2.

Week 1 saw several surprises in the top 10, including Daniel Jones , Aaron Rodgers , and Michael Penix Jr. At the same time, other quarterbacks struggled, and many had pegged them as set-it-and-forget-it fantasy assets in their weekly lineups. I'm looking at you, Joe Burrow , and Bo Nix . We also have our first potential loss in Brock Purdy (shoulder), which fantasy managers must now navigate.

With that in mind, here are

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