Police are investigating the fatal stabbing of a man in the Northern Rivers region of New South Wales.

Emergency services responded to reports of an assault on the Gwydir Highway at Waterview at around 1am.

Police found a 35-year-old man had been stabbed by unknown assailants while walking along the street.

He was treated by paramedics but died at the scene.

Homicide detectives are assisting local police with the investigation.

Police say initial inquiries indicate the stabbing was targeted.

Drivers are being advised to avoid the area, which is expected to remain a crime scene for a considerable amount of time.

Anyone with information about the incident is urged to contact Grafton police or Crime Stoppers.

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