The Oregonian/OregonLive is back with its picks for Week 4 of the 2025 college football season, highlighted by some of the sport’s most passionate rivalries.

The No. 6 Oregon Ducks host the Oregon State Beavers at Autzen Stadium in the latest showdown of the long-standing series. The Ducks are coming off a dominant road win at Northwestern, while the Beavers are still searching for their first victory of the season after a brutal start against a difficult non-conference schedule.

This week also features several other high-stakes matchups, including No. 17 Texas Tech traveling to face No. 16 Utah in a Big 12 clash, No. 9 Illinois at No. 19 Indiana and No. 4 Miami hosting Florida.

Here are The Oregonian/OregonLive staff picks for a dozen games:

Season totals

Straight up

Bill Oram:

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