The San Francisco 49ers are taking on the Arizona Cardinals in their home opener of the 2025 season in a divisional battle between two undefeated teams.

San Francisco kicked off the year with a 17-13 road victory over the Seattle Seahawks before their 26-21 win over the New Orleans Saints in Louisiana last weekend.

Both wins have come with some strong defensive play to close things out, as Robert Saleh’s unit has performed well, despite relying on younger pieces to step up and play.

San Francisco will likely be starting Mac Jones for the second straight week. Brock Purdy was a limited participant in practice this week as he recovers from his toe injury, but head coach Kyle Shanahan said it was highly unlikely he’d start on Sunday.

It’s unclear whether the 49ers will have Purdy as the N

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