The Week 3 NFL schedule has an interesting blend of divisional rivalries and cross-conference showdowns. The former has Texans vs. Jaguars, with Jacksonville 1.5-point home favorites in the Week 3 NFL odds, while Colts vs. Titans has Indy favored by 4.5 points. Then, there are contests like Bengals vs. Vikings (-3), Chiefs vs. Giants (+6) and Ravens vs. Lions (+4.5) These AFC vs. NFC matchups aren't as common, thus possibly giving them a bit more appeal to make Week 3 NFL predictions on.

A couple of weeks under the belt also gives sportsbooks a clearer picture into how good, or bad, teams are. As a result, there are wider NFL spreads this week, with four games having a line of at least a touchdown. Should you back big favorites like the Bucs (-6.5) versus the Jets or the Seahawks (-7) aga

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