Arizona Cardinals two-time Pro Bowl running back James Conner was carted off with an ankle injury in the third quarter of Sunday’s game at the San Francisco 49ers.

Conner had his right leg bent awkwardly underneath him while being tackled near the line of scrimmage on a carry. He immediately appeared to be in a great deal of pain and was loaded onto the cart with teammates all around him.

Within minutes of being carted off, Conner was ruled out for the remainder of the game with an ankle injury. He finished with 22 yards on nine carries and had three receptions for 15 yards.

Conner, 30, is in his fifth season with the Cardinals after spending the 2017-20 seasons with Pittsburgh, which selected him in the third round of the 2017 draft.

Conner had the first two 1,000-yard seasons of his

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